I was wondering how it would work with a power drill?
It won't. It enlarges the holes in the plexi and the chips get sucked up into the hole, causing the bit to bind, overheat, and melt the plastic. It's more of a locating device, but can work with the pin drill if you clamp it to the barrel.
I was going to make these to sell but drilling all the holes proved problematic. Took 2 hours apiece to make them....after I found the right lube, several snatched bits, and melted plastic.