That is a beautiful piece. The gun looks to me to have a lot of Bull family characteristics - so my guess would be Tennessee or Alabama. The buttplate, the shape of the guard (although the configuration is a little different), the patchbox, the entry thimble and the mixed iron and brass, and the architecture - all look to me to have strong Bull family ties. I have seen similar features on guns by both John and Elisha Bull.
On the other hand those triggers are unique - I've never seen any exactly like them. Although the Jacob Young/William Whitley rifle has a smaller pierced tab on the back of the front trigger - it was probably made in middle Tennessee or Kentucky.
Guy