With the lead of Jacob F. Brant and the engravings on the lock and patchbox, here is what I have found so. Anybody can chime in with their ideas and info.
Brant, Jacob F. Union Township, Fayette County,Pennsylvania 1835-1851
Brant, Jacob F. Pittsburg, Pennsylvania 1852
Brant, Jacob F. 46 St. Clair Street, Pittsburg, Pennsylvania 1855-1858
Brant, Jacob F. 4 Fifth street Street, Pittsburg, Pennsylvania 1859-1865
Haddon's History of Uniontown of 1913:
Brant became a partner with Samuel McCosh known as Pittsburgh Gun Works and separated in 1855. Most likely the guns marked J.F.B were made by Jacob F. Brant.
John Sowers was a gunsmith and a partner in the Sowers & Smith firm. Sowers & Smith are listed in McElroy's 1855 Philadelphia Directory. The firm were Importers of gun locks. Locks sold by the firm were marked Sowers & Smith from 1840 to 1855. These locks were used by any number of gunsmiths of all sorts of muzzle-loaders of the period.
The Eagle Rifle/Gun Works, manufacturers of percussion Kentucky rifles, was operated by James Golcher in Philadelphia and was in business from 1833 to 1851. The company was located at 138 N. 2nd Street. His father was William Golcher from Birmingham England. James sold gun locks and parts for use by other gunsmiths across the state.
James Golcher of Philadelphia died in 1880, in 1850 he employed 17 workers who made 600 dozen gun locks to be sold.
He signed guns Jas Golcher, maker of Deringer-Style Pocket Pistols, muzzle loading shotugns Pennsylvania style rifles. In the early 18th century the Golcher family was known as gunlock makers. James and John were riflesmiths. There are Kentucky style rifles signed Jas. Golcher/Lancaster. Likely the same.