"... that the positioning of the lock is pretty well fixed."
Within narrow limits it is fairly fixed, but there is some wiggle room. Once you locate the touch hole you key off of it as has been mentioned. The wiggle is in where you place the nose and tail of the lock. If you intend to have a forward lock bolt it should go through the web under the barrel and above the RR channel. If you aren't going to install a forward bolt then no worries about positioning the lock for one. The tail should be a hair above the centerline of the wrist. If you can't get it there then put the tail on the centerline.
Once you determine where you want the lock, and have filed a slight bevel around its peripheral, and removed the lock internals, then lightly clamp it in place and begin your initial cut into the wood defining the outside of the lock. The bolster goes in first, you are aiming to have the lock pan centered on your touch hole and the hole in the "sunset" position relative to the pan. Inlet the bolster and lock plate until the bolster is snug and square against the side flat of the barrel. "snug" means you can't get a slip of paper between the bolster and barrel. If you have to remove wood off the lock panel as the lock plate goes deeper, do so. Once that is done begin to add the lock internals and inlet those. Remove as little wood as possible, as this is a weak area, and you want as much wood remaining as possible as long as the lock functions freely once you are finished. It is the same with the triggers, leave as much wood as you can as long as the triggers function as they ought to.
Your double-set triggers key off of the lock, specifically the sear bar. Be careful of where you inlet the trigger bar, that little adjustment screw hole on the bar between the triggers should be positioned immediately above the sear bar. Remember that when inletting on a curved surface you begin at one end, usually the forward end, and inlet to the other end, and that the adjustment screw hole will move a tiny bit forward as you inlet the trigger bar.
dave