I've used TiteBond 2 for about as long as it has been on the market. It is an excellent glue if you can apply enough clamping pressure.
The only drawback that I have found with it here in the Southwest, as the wood shrinks the glue leaves a glue line proud of the surface.
I have used titebond 3 and really like it better than TiteBond 2. It has a longer working time and is less viscous than TB 2. It supposedly has gap filling qualities. I just jointed some Hickory boards together and have not seen the fore mentioned problem.
that glue line problem is common with just about any glue there is. as a glue cures it reaches a point of innert stability, where moisture doesn't change it's dimensions.at that point the wood can still move with atmospheric conditions where as the glue line does not, hence, as wood shrinks when ambient moisture is at a low ebb, the glue line remains the same as when the joint was originally glued. there are glues that move with the wood's movement, but these glues are also susceptable to creep, which means shear loads placed on the joint can and will displace the relationship between the two pieces that are joined. there are instances where this can be advantageous, because extended periods of such movement can break a glue joint that has little to no elasticity. there are a few marine glues that are rigid, but they require fairly high clamping pressures to achieve a glue line that is almost imperceptible, so that the wood movement between the two pieces is unison and the glued boards act as one piece. most dry powder mix glues and Titebond 2 and 3 are such glues. there's a reason boat builders have all those clamps !