I'll take a shot at this, the butt looks like it is done in the Bee Hive manner. I'm thinking the lack of Bands and or an applied One or Two piece tip of Antler leaves it out of N.C. The finial is more Acorn shaped, pointed than most of the N.C. horns I have seen, they are flatter. The lip on the tip reminds me of a couple Southwest Va. attributed horns I have seen.
The Leather stopper is a Southern thing, not to say they were not used in other areas (Doubt any horn ever came out of a shop with one) Jim Webb mentions them in his Sketches of Hunting Pouches Powder Horns an Accouterments of Southern Appalachia
Some horns are easier to attribute to an area, for me this is not one of them. Very nice horn and would fit well in any Southern collection.
How big is the hole in the tip? I'm wondering if maybe it was a shot horn.
Thanks For Posting It, Tim C.