Bob,
Yes, slant to follow the barrel profile. It is funny you should ask this now... I'm building a mid eighteenth century British fowling piece at the moment and found something interesting about the ramrod groove and hole. A characteristic of British fowling pieces of this period are barrels that have a large breech, often in the neighborhood of 1 3/8", but a narrow barrel waist, often just a little over 3/4". As you can imagine some care needs to be taken to position the ramrod groove and hole to obtain a slender forestock. I have a couple of original examples I've been studying and found something interesting. The ramrod groove follows the profile of the barrel. The web of wood between the barrel and ramrod groove is a consitent thickness along the forestock. This allows a slender forestock, but positions the ramrod hole below the barrel channel at the breech. One thing I've found by having original guns to carefully study is that assumptions we take for granted, may not be true. It becomes obvious that a modern post industrial revolution mindset in terms of layout, design and construction often doesn't apply.
-Jim