Many position the vent liner so the rear edge of the threaded vent hole will be just in front of the breech plug face.
i.e if its a 1/4" liner, the hole is centered at (1/4"/2)+1/32" = 5/32" forward of the breech plug face. This of course is determined when locating your lock plate, on a given breech plug face.
Most do remove breech plug prior to drilling vent hole.
If the drillbit intercepts the breech plug face, it will deviate and create an oval hole.
/m