The larger the powder charge, the tighter the load must be to remain sealing. If powder gasses can leak past the ball and patch combination, the leakage will be variable and the shot to shot presssure will fluctuate more and that lack of or reduction in consistancy will enlarge groups.
The illustrate this, with light loads, to 100gr. 2F, a simple .020" patch (mic'd) worked fine (if 2" at 50 yards is fine) in my .69, but with 120gr. the groups opened up to over 3". Picking up the patc hes revealed inconsistant burning in spots, which changed, patch to patch. Increasing the patch thickness to .025" showed the same accuracy as before. but as the powder charge was increased yet further, from 140gr. all the way up to 200gr., accuracy was in the minute of angle range, to 1 1/2 MOA from 50 yards right out to 200yards.
Plastikosmd is not shooting a shouldered, offhand-style trail walk or hunting rifle at 25 or 50 yards. He's shooting oversized balls with thick patches in a bench gun at from 100 to 200yards - a different sport entirely.