"1. Is this lock appropriate for an English-style Big Bore sporting rifle?"
A back action lock on a 1840-60 percussion sporting rifle would be somewhat unusual, as conventional front action locks are by far most commonly seen. With that said, because of the 1 1/4" inch barrel you mention, it happens that the dimensions would come close (depending on bolster/breech) to allowing you to use this lock. But there are some considerations.
If you look closely at the pictures of the Blackley parts, notice the sear. It has the "offset" or "step" also found on the lockplate, bridal, mainspring and sear spring of this lock. This "offset" allows the architectural transition from an action width of 1.600" down to 1.150" width of the wrist.
A picture of an original lock from the top:
Here is a better look at the "crooked" internals on a original and a new lock
The Blackley hammer casting would require more effort and work to adapt to a 'percussion conversion' than it would be worth. You would have to make a new hammer because the angles and dimensions are just too far off.
By the way, the Alex Henry locks are not rebounding, rather the forward movement of the hammer is stopped as the flat on the bottom of the hammer throat comes in contact with the top action corner. So, once again you could make a new hammer which stops the lock upon hammer contact with the nipple.,
As to making one of these locks from castings, Tom's advice is sound. It would be difficult. The tolerances required are quite close.....more so than a conventional lock.
Jim