Jamie,
I'm no "expert". But I build my rifles to shoot. So the shooting characteristics of the guns I build are of paramount importance. That being said, I build the rifle around the touch-hole, not the other way around. Once the barrel is let in I spot the touch-hole at the center of the side flat far enough forward of the breech face to allow the vent bushing to be installed without collision with the breech plug face. I then position the lock to maximize the effectiveness of the lock relative to the vent (touch-hole). Since I usually use Chambers locks which have a detachable flash-pan I detach the flash pan and let that into the stock so that the vent is bisected by the top surface of the flash pan. Once the pan is let, I re-attach it to the lock plate and let in the plate. Then I let in the rest of the lock. Once the lock is let in then the trigger is positioned. Once the trigger is position the butt-plate can be located. The, and only then I carve the stock down so that it forms an integrated whole with the metal parts(i.e. the top of the lock flats even with the top of the barrel side-flat, etc.) This approach maximizes the shooting effectiveness of the gun as a whole. This approach is also limited to building a rifle (gun) from a blank. If you are using a pre-carved stock the lock inlet is already there and you have to let in the lock and then adjust the barrel in-let to put the vent where it belongs relative to the flash-pan. In my view a gun that looks "purty" but doesn't shoot is a failure.
There are many who chafe at Mr. Alexander's writing style, which implies that his way of doing things is the ONLY way and it is the RIGHT way. I have read his book, I refer to it from time to time. But I don't view it as a gospel.
And finally, I reserve the right to be wrong in someone else's view.
Best Regards,
John Cholin