I would personally use 90gr. 3F, or more likely, 100 to 110gr. 2f in a .50 for moose or elk within 120yards, no problem. I would not use 85gr. 2F or less as I feel something over an initial velocity of 1,408fps is required for moose and elk and that low velocity is all 80gr. 2F gives in Taylor's 42" Rice barrel. A .50 should shoot flat enough to 120 yards that no thinking of holdover or sight change should need be thought about.
1,850fps through 2,000fps will deliver an exceptional point blank range, one where the ball is never more than 2 1/2" over nor more than 2 1/2" under the line of sight. That's a 5" zone of death. With sights held level from 25 yards to 120 yards, the sights for hunting, in my opinion, should give a p[oint blank range to at least 120yards- which means limiting to an estimated 100 yards on big, heavy game. This allows an error in range judgement of 20 yards to be still within point blank shooting range and still able to kill cleanly. in my opinion.