Both of my bison were with the same .58; a 36" barrel with 1/72 twist. 110gr of 3F is the load, not because I think it takes that much, but because the rifle likes it & hates 2F. I talked to Doc White about bison hunting a couple of years back & he had quite a bit of experience with round balls & buffalo. He mentioned that he had seen many shot with .50 & .54s with mixed results, but his .62 (or .69, I can't remember exactly) was pretty sure fire on bison. I would think that a .54, heavily loaded, would be OK and anything larger that you can shoot well would be even better. Read any of the fur trade journals on bison hunting & you will really get the idea. If they wind you, they don't run 100yds & look back. They stop about a mile later. In my experience, they can be hard to kill & slow to die, even when well hit. Knowing the anatomy is critical, as the bison presents a huge mass, but a small & well protected kill zone, low in the chest. I suspect that small caliber guns, poor knowledge of anatomy, & bad range estimation is why most of the fur trade "greenhorns" banged away at bison their first time out & came away empty handed. I've also seen a herd surround & guard a downed animal with some hooking her with horns trying to get her up. If they are truly wild (like the Henry Mts herd in Utah) they can be a real challenge to hunt. And then the work starts. Bring lots of sharp knives or a few good ones & as many sharpening stones.
Roger B.