I've been playing this game for a lot of years, sighting in iron sighted rifles, ML's and others. I have never resorted to mathematics and measuring with calipers to find what is needed. File a bit and shoot, file a bit and shoot, drift a bit and shoot - works every time.
If math is your game, then have at it, I guess, but I'll have been sighted in perfectly while you are still measuring & figuring, then probably making a mistake and fussing abotu the math. It is far easier to file off a bit, then test, file, test, than it is to figure the amound, measure it out and scribe it, then file to the mark, check, file, mark, etc. You'll need an accurate set of calipers and a magnifyiing glass & then probably end up filing and shooting, filing and shooting the way 99% do it.
With a ML, a quarter inch at that distance isn't critical, except maybe a bullseye shoot off bags & it will take 6 to 10, 5 shot groups to see that the suspected 1/4" is actually a true 1/4" error - which is then easily adjusted - another swipe with a file - going up 5gr. might do it as well, if it's elevation needed. (I never go down in charge - HA!)