My computer program gives a .395" ball having a ballistic coefficient of .055, and an initial velocity of 1,350fps, a max range of 570yards. At 25 yards, the ball is 55.89" above the line of sight - that's 4.65feet - not a lot of angle, but anything greater, reduces it's maximum range. Shooting up into a tree, while not the best way to fire a shot, presents little possibility of harm unless a populated area is close by,which is doubtful if you are out hunting.
At 2,200fps, it has a max range of 641yards. The at 25 yards, the height above line of sight is 50.44"- or 4.22feet so you can see the angle of departure is not anywhere near as steep as shooting up into a tree. At anything more accute than this angle, the maximum range is reduced.
As can be seen, the angle of departure for max range with a round ball is considerably lower than with elongated projectiles. I can only surmise this is due to the rapid decay of velocity with such a low BC projectile.
I make the max range for a .535" ball at 1,350fps - (70 to 75gr. 2F) as being 777yards and is 76.67" high at 25 yards, which is 6.39feet.