Brett,
I've used the 46" barrel in a Krepps, Armstrong, and several Virginia Piedmont rifles. I love the profile and balance achieved with these barrels, and the ones I shot, performed very nicely. As to the Bedford consideration, that's up to you.
If you're looking for something slim, I'd take a look at the new "A" weight profile that Rice has. I don't believe it's available in 46" (42" or 44"?), but it's a wonderful profile that makes for a very nice and slim piece. Plus, you can get it up to .50 cal. Best of luck!
Ed