Looks like an interesting rifle. The guard and buttplate look to be iron to me (?).
The hardware and architecture would seem to place it somewhere in the southern Appalachians or adjacent areas. The triangular greasae hole surrounded by a brass inlay is unusual. Never seen one exactly like that before. The guard has an early profile, as far as rifles from this region go. Single triggers are very unusual for this region, and I am guessing that the original triggers were replaced. Perhaps this rifle may have been a very old restock of older parts. But the architecture is nice, so perhaps not.
Hard to say on where it might have been made - really a rifle like this could have been made anywhere from southwest Virginia down the mountains all the way to Alabama or adjacent areas - North Carolina, Kentucky, even Ohio. However, the guard shape and architecture looks to me like something you might expect out of western piedmont North Carolina, although the guard is much heavier in feel than most iron guards from that region. If I had to throw out a guess I would say western NC, but I am sure others may have some alternative ideas.
Hopefully someone else has seen that odd triangular grease hole before......