If you use commercially cast or cut side plates, you must be very careful in their selection so that lock bolt placement is not a problem. It is far easier to put the lock bolts where there are best, and then make a sideplate to fit...everything is a lot happier. Side plates , made out of 1/8" brass sheet are fun and easy to make, and add a lot to the hand made appeal of the rifle.
I like to get the rear lock bolt as far back, and low, in the plate's bolster as I can. Even so, almost always, I have to drill though the breech plug lug. I make that hole with lots of clearance so as not to have conflict between the barrel and the lock bolt. Often, the hole gets opened up in the back, but the lock always comes off the rifle first for cleaning anyway, so that is not an issue, for me. I agree, again, with Tom...lock bolts with large heads are lovely. A 1/4" x 20 tpi carriage bolt makes into a great lock bolt, turned down to 3/16" and threaded 10 x 24. Before I had a lathe, I used my electric drill clamped in the bench vise, and a file to make 'em.