I have two guns with Chambers' big round faced English lock. They prefer bevel up, and give reliable and consistent performance this way. But once, when the flint was worn, I tried it bevel down so it would strike higher on the frizzen, and that worked, to extend the working life of the flint, but ignition was noticalbly slower. the sparks are shot forward of the pan, at the frizzen's hinge point, and though I got ignition, it was not as reliable or as fast as when the bevel was up.
All my locks, regardless of maker, prefer bevel up.