Like LB, I use one charge for all ranges - whether it's a card on edge at 15 yards or a steel bunny plate at 105yards. Which lube I'm using dictates what that charge is. If using a water based lube in my lapped .40, 48" twist Goodioen 36" barrel, I can use less powder than with an oil or grease patch. The water based lube I generally use is WWWF + Neetsfoot oil, get a charge of 55gr. of 2F or 3F - shoots to the sights with both. 25 yard zero is a 50 yard zero and the diameter of the front shiny part (45 degree angle on the blade gives about a 1/16" shiny dot) over the rear sight, gives a Zero for the 'around' 100.yard targets on our trail walk.
When this barrel was 42", several days of bench testing showed that if using Neetsfoot oil, mink oil, Lehigh Valley or Shenendoah lubes, I had to increase the charge of 3F to 65gr. and the accuracy load with 2F proved to be 75gr. - those increased were required just to maintain the accuracy level that the lighter charges gave with water based lubes.
This barrel gets a .398" ball (Lyman .395" mould) in it's .398" bore, along with a .022" to .023" denim or ticking patch (whichever I'm using). It's easy to push down the tube and although a short starter isn't necessary, it's easy and quick. Patch measurements are from dial calipers squeezed as hard as I can between forefinger and thumb, with the cloth on the wide part of the anvils. This way, I get consistent measurements. For instance, I measure OxYoke's .018" patches at .015" they have proved to me they are too thin for ANY of my rifles. I and they prefer thicker patches.
I've also used a .400" ball with the same patches, however that mould is a pain due to one cavity casting oblong balls, while the other is perfect - have to keep the castings separate, so it's easier to simply use the bore sized mould- which isn't quite as accurate.
WWWF + oil is Winter Windshield Washer Fluid with about 2 ounces of Neetsfoot oil added to each quart. I shake it, then pour it over the pre-cut patches , squeeze them out just a bit, then store them in my possibles along with the balls for the trail that day. I try to only lube enough patches for the day's shooting as adding lube to extras if they dry out over the week for the 'next' shot, introduces more oil and changes the poi and accuracy.
When using Neetsfoot oil, track's mink oil, Shenendoah or Lehigh Valley lubes, there is no buildup of fouling, even though the charges are higher. Velocities with the heavier oil lubed patches (65gr. 3F and 75gr. 2f) produced just over 2,200fps in the 42" bl. The water based lube velocities with the lighter charges ran in the 1,700fps to 1,800fps range.