Hurricane, Antlers have cancellous bone in their centers like the bone on your box. Different sections of antler and different species have thicker or thinner cortexes. The "heart" inlay especially seems to have very thick cortical bone. I am guessing antler as the source, since long bones with cortex that thick tend to have no cancellous bone in the sections of the shafts with such thick cortex. Could be American, European, Asian, or even African animals, I suppose. Want to bring it to KRA and let us have a look? You certainly have a lot of folks offering opinions on a challenging item! I like the idea of DNA analysis. Sounds like you have a friend in a sophisticated lab. See you "on Mars" at the KRA. Bill