It makes a difference. Go to Hornady Ballistics Calculator. From that page select Advanced Ballistics Calculator. When that comes up, select from Basic to Advanced. Your Ballistic Coefficient for a .54 roudball is about .075. Weight of ball about 225 grains. Velocity- if you don't know, I can give a close estimate from your powder and charge. Maximum range- I'd go 200 yards. Interval- use 25 yards. Zero range- 125 yards. Sight Height- .75 inches. Wind speed- use 10 mph. Temperature- 40 degrees. Altitude- whatever. I just hunted at 7200 feet. Here you can change it and see what difference it makes. My range is about 6000 feet, but the extra 1200 feet lessened the drop at 200 yards. You try out some different inlputs and you will see. This is a wonderful calculator, you can print out your results. Try different sighting ranges, velocities, and so on.