I have only once built a rifle with a drum and nipple. It was in my very early days of building muzzle loading rifles, and it was with components supplied by the client. The latter of those two scenarios will never happen again. I insist upon providing the parts for every build now. Then I know what I'm working with, and can take responsibility.
In the case above, the rifle had a 13/16" parallel barrel, and in .45 cal. The Drum supplied had a 5/16" x 24 journal. It concerned me that there was precious little contact in the barrel wall, and in the end, I was right....the drum blew out. My fix solution was to convert the rifle to flint, and install a 3/8" x 24 stainless shop made vent liner. The rifle was stolen shortly after that, and has not surfaced in these 40 years since.
Now, I have made drums and patent breeches with drums since that time. But I make the drums myself and use a 3/8'x 24 tpi journal, which provides much more strength in section. I made a jig for tightening the drum into the side wall which simply involves a 3/8" thick steel plate with a 1/2" hole drilled through it, and an allen screw to jam the drum. Once the drum is bottomed firmly, I stamp it and the barrel with a witness mark on the side flat forward of the drum. Then it can be removed and returned to the same tension each time, but that only happens a very few times during the build. The last thing that gets done, is drilling and tapping the nipple seat. And I never drill right through for a "clean out screw!!" It does not bother me if the shaft is larger in diameter than the side flat of the barrel...I have seen very few original rifles that were otherwise. This gives confident strength in the threaded journal in the barrel wall, and also sufficient metal into which to seat the nipple. And always, the drum is supported by metal to metal by the lock plate.
I see no reason, if you are careful about these details, that drums cannot be used for rifles such as the Bedford Co. rifle. I believe the Vincent is another such rifle. Start with a barrel with a decent wall thickness, and carry on. Roger Fisher's favourite rifle has a drum and nipple and has been used successfully and safely for dozens of year and some 40,000 rounds. Just one contemporary example.