They're pretty close and a .54 will certainly kill near bout anything very dead, but there's so much more than just caliber. Weight, length, style, etc all matter as much or more, as well as how you intend to use it.
I always think about hunting first when deciding a build. For example, my main rifle is a .54 with a 44" swamped C weight octagon. It's not overly heavy, hunts well, single trigger, but it is a wee long in treestands and blinds. Next thing on my bench is a .58, but it's got a 38" Oct/Rnd rifled barrel, single trigger and is going to be a featherweight with a big buttplate (Early P Berry (SR?) ) stock. Would never think about that as a range gun, but for carrying all day and then making one shot that counts? Oh yeah. Only jumped to the .58 because of hopes for a moose or elk hunt someday and I got the barrel on closeout, and if I leave flatlands for mountains every ounce I have to carry counts. If I was looking to make a range rifle neither of those would be my choice, so just plan ahead on expected use.