When shooting long ranges - a rifle (or smoothbore) needs more powder. It's a fact.
About any powder charge will work at 25 yards, that is, even 25 to 30gr. will put 5 shots into a single hole.
When you extend the range to 50yards and beyond 100, simple testing will show the need for more powder.
When hunting out West or in areas that require shots to 120 or 150 yards, the need or desire for a flatter trajectory weighs in as well, thus more powder is needed. To- when using one of the slipperier lubes, more powder will be needed to stabilize pressure variations shot to shot and thus maintain accuracy. The benefit is not only flatter trajectory, but improved accuracy as well.
I did a preliminary range test in my new .50 using 2F powder. What I found was that 85gr. 2f shot well at 50yards. I didn't even try it closer in, as I know from experience, that it's the longer ranges where accuracy is needed. Any load that shoots well at 50 or 100, will shoot well closer in.