I only make sure the top and lock side of my blank are straight and square, but you do need that as a minimum to layout everything correctly. As you proceed, you should look often to make sure everything makes sense. This is where I often fail. Layout everything and think about everything as it will affect the entire build process. When I think I know what I am doing, that is when I make a mistake.
Specifically, with regards to the barrel, I find the most important part of the process is to set the center line of the barrel in both planes. I then measure off of that. The center line of the barrel should carry the full length of the stock on the top and then be intersected by the offset line of the butt stock at the rear of the lock panels. I actually draw the center line of the butt stock first as I need that to figure the offset of the center line of the barrel. I start by placing the butt piece lined up with the right edge (if a right handed gun) of the butt stock. I then mark the other side of the butt piece; extend that line to the top to give me the full width of the butt piece on the top right edge of the stock blank. I then figure the center of those two marks and draw a line parallel to the right side of the stock blank. I, next, draw another parallel line 1/4" to the left of that line. That last line is the center line of your barrel. I hope that makes sense.