I started off with a .50 cal. TC - it liked a .20 thou. patch and .495" pure lead ball driven by 80gr. 2f GOEX. We now know that early GOEX was under powered compared to today. I did not shoot anything other than paper with that rifle.
My current .50, the Verner, with a Getz bl. I assume, 56" twist, shoots reasonably well with 82gr.(3 drams) 2F on the trail, but if I did want to use it for hunting, I'd likely see how it shoots (actually test it) with 100gr. 2F, or 82gr. of 3F. I know it would shoot better with those loads, than the 3 dram 2F load. What I do not know, is if I'd need a thicker patch- which is likely, due to the higher pressure generated.
Considering the 14 bore is THE ultimate hunting rifle imho for NA, I will continue to use it for big game - if using a ML.