I'd have used a 48" twist in my .45, however was after a trail-match + hunting twist, so chose the 60" GM barrel. Yes, it requires a descent charge to shoot well, oh well, it doesn't kick at all, being a .45 of 9 1/2 pounds. It's preferred charges are 75gr. 3F or 85gr. of 2F - some what heavier than the norm for most shooters of .45 cal. rifles. I see no difference in fouling as they both shoot seemingly 'cleanly' in that the bore is wiped by the next ball/patch to the bottom of the grooves and no fouling builds for a day's shooting.
The 48" twist has long been a favourite of bench shooters, but be aware it requires more care, I think in developing an accurate load. Being, that is may want a specific charge and 5gr. above or below that might not shoot well at all.
The .40 cal. barrel I have is a 48" twist and is somewhat particular in it's diet depending on temperature, it seems. In the winter, (sub freezing)it seems to prefer a light oil lubed patch, while in the summer it likes spit - same patch, but with 2f and a lighter charge as well. Winter uses 65gr. 3F while summer uses 55gr. 2F. With 2F, I have to prick the vent each shot as if I don't in 2 to 4 shots, a piece of fouling at the pan will block the vent. It's easier to prick it each shot - HA! - if I don't though, it shows if I'm flinching when it 'foof's on a blocked vent.
I think twist might depend on what your accuracy requirements are, Tom. I've a feeling the 48" might be more accurate than the slower twists - but perhaps a bit more finicky to loading. The larger the bore in a 48" twist, perhaps the more finicky. On the other hand, my .58 has a 48" twist and it shoots well several loads and isn't as finicky to lube as the other two barrels. It does not like heavy charges, though, however will shoot well enough with them for hunting purposes.
The barrel will, of course, will you want it wants or demands. There isn't much difference between 48" and 60", but small differences like these seem to matter.
I think you can find a load that will shoot amazingly well is a very fast twist like they guy with the Scheutzen rifle. But one like that might be a close range rifle only. With lower velocities, higher trajectories. I'd not go faster than 38" .50 cal., which shot for me with round ball only after I choked the barrel.