My experience is that the flat bottom rifling is much easier to get to shoot well than round bottom. I believe the issue lies in some builders making the round bottom grooves too deep to seal easily (or at all). You get in a fight between a patch thick enough to seal, versus how much ball & patch combo you can drive down the bore.
I have not seen that round bottom barrels are easier to clean. I think that is because they are harder to seal, and therefore blow more fouling by the patch and make more mess. Again, just my experience. Of course, Daryl's wet patching method would help with that a lot.
At this point in my life, if a builder said "Here's one of my round bottom barrels, and here's one of my flat bottom ones. My flat bottom is twice as expensive", I would still pay the extra to get flat bottom.
I hope this helps.
I do have experience with a friend's Tip Curtis rifles with Colerain round bottom rifled barrels. The rifling is shallow, and is easy to seal and shoots very well. Not contradicting my above message, it is just that Colerain's shallow round bottom rifling method works. Credit where credit is due.
Best wishes and God Bless, Marc