A lot of the guys that use the synthetic use those little cylinders or rectangles - supposed to be 50 gr in each one.
So, several years ago I was gifted a new .50 cal (edited to meet ALR rules).
Got some of those cylinders of synthetic and off to the range.
I fired 10 rounds - they were lined up vertical, above and below the bull (100 yd range), but varied from barely on the paper at the bottom, to nearly off the paper at the top. 3 of the 10 were in the black. I call that laddering, and when I returned home, I weighed each of the cylinders on my powder scale. There was up to 10 gr difference between lightest and heaviest, and no two were the same.
Next time I went to the range, I used Goex, and had several weights already weighed out. I found that 95 gr Goex 2F would put each and every round right through the 10 ring!
PS - the Goex was absolutely easier to clean - bit of hot soapy water had her looking like new.