Back in about 76, I finished off a deer with my wife's .36 Seneca using 60gr. 2F and a 128gr. maxi-ball. I had shot the deer when facing me, through the neck, but the round ball missed the spine & exited, however dropped him in his tracks. I reloaded, advanced and missed his head as he was throwing it around. She handed me her rifle & I re shot at it's head, the bullet missing, but entering the neck, about 1/2 way down, traveled the length of it's neck and entered the spine went down the cord then stopped still inside the spine, at the base of his neck.
A broadside shot would work on deer, I am sure, but it is not something I would attempt as I have better guns for the purpose.