My findings are that unless you hit and disable the nervous system , ie brain, neck, spine , a deer will run until the oxygen is deprived from the brain and it shuts down. Lung /heart shots work by rapid blood and pressure loss. Therefore, the bigger the hole, the better. I have 20 acres of property. Cross the fence and it's either Crown land or the neighbour's land.
Either way, it usually ends up with someone else claiming the deer. Since I began using round balls in .54 , .62 and up, I haven't lost one deer. Now, having said that, my friend hunts with a .45 I built for him and he hasn't lost a deer yet either.
He has open fields on his property, while I have thick woods