Much depends on the last 6" of the bore, whether they "run-out" off centre or not. If the last 6" are square with the world, there will be no angling of the 'shot'. If, however the hole/bore
is straight, but on a straight-edge angle inside the blank, then the ball will follow that angle, compared to the sights & as Taylor indicated, the ball will be projected at that angle, compared to the
top flat.
When a barrel heats up, it will likely bend towards the thinner flat/direction, causing even more shot displacement. It's best to have a perfectly straight hole obviously, but that doesn't always happen, even when the holes come out in the middle of the blank, both ends. The drill can wander inside the barrel and it does, at times. The better the equipment, the less likely this can happen
but it still does.
It's a $#@* shoot, but will likely be OK.
Oft times, the hole comes out not in the middle of the blank, however the rough bored barrel is then chucked up on centres and the flats milled giving the appearance the hole was bored straight. Douglas bored octagonal blanks, with the flats already there, thus when the drill wandered, that became a standard barrel, not a XX (special) higher priced barrel.