I use 3 different guns also. When I'm going for buck or bear, I use my 50. Doe's. I use my 45. Small game, I use my 32. I also have a musket for turkey, but that don't count. At shoot's, I use only my 50. With one exception. when we have the small caliber, competition.
My 50 is the first gun I ever built. I built it when I was 16, and now I'm 53. It originally had a 40ish cal. hammer seamed barrel. In the 70's I bought a factory barrel and installed it on the rifle. I've shot 1000's of ball through that barrel with the same load, 65 gr. 2f. Once I sighted it in, I've never changed. I know exactly where that ball is going every ahot.