Well if were going to great lengths, had the space, money, and high-value collection; I'd say have two safes, one that isn't so terribly difficult to find (the decoy) and a second safe that is properly secured and difficult to deal with. Keep the good stuff in the hidden safe.
My favorite approach is a bank-vault type room, as the one I worked in at the engraver's place. Genuine bank vault door on a filled block room. Make the room any size you want, then build your home or shop on top it it.
Camouflage can be more effective than safes as I heard of a local case years back that went like this: Guy had a lot of his guns out of the safe for cleaning and such. Left the home for whatever reason with the guns out, and simply threw some bed coverings over multiple guns on the bed and floors. In his absence thieves broke in to the house, and broke into his safe and stole everything in it. However they walked right past all the unsecured guns they couldn't see.
I have a safe, but don't bank on it being full of anything.