The only loads I use in almost ANY of my rifles, are the gun's accuracy loads with THAT ball and patch/lube combination.
My accuracy loads amount to 40gr. 3F in a .36 with water based lubed .021" patch. In a .45 was 65gr. 3F with water based target load, but 75gr. with same patch and slippery lube.
I would put Mink oil in with slippery lubes, for a hunting load. My .45 gave virtually identical accuracy up to 85gr. of 3F which I feel is about 10gr. more than necessary. 75gr. gave 2,200fps
with the combination noted such as mink oil, 10 ounce denim at .021" and a .445" round ball.
My .50 uses 85gr. 2F, the same load that worked best in my .45, with that same 2F powder & greased patch.
All of my recovered patches, no matter the calibre, are reusable.
The muzzle's crown is vitally important in allowing easy starting and loading of these snug loads by not cutting the patch, as most all factory crowns are known to do.