Hi,
Generally, they will true up nicely. I do this job with a simple wood lathe, fliles and stones. A metal lathe would be better but I achieve all the precision I need for a good working lock. I place the large spindle in my lathe chuck first. Rest a file with safed edges on edge on a tool rest, I spin the tumbler and true up the side. Then I place the safed edge against the side of the tumbler to clean up the big spindle. Usually, it takes very little filing to true up the sides ad spindles. Use a medium or fine cut file and be careful the spinning toe of the tumbler does not catch the file. Next turn the tumbler around and do the same on the other side. The bridle spindles on Bess locks are large so don't take off much diameter. Next, I repeat the process using stones and oil. Keep in mind JMF, you are not building a jet engine with spindles that turn thousands of revolutions a minute. You want the best precision you can do but you don't really need a CNC milling machine to build a fine lock. I urge you to buy a copy of Goldstein and Mowbray's "Brown Bess", which is an invaluable asset for building the locks and the guns. The only thing better is an original in your hands. Another tip, if you can, heat soak the cast parts at about 800 degrees for 15-30 minutes and let air cool before working on them. Sometimes, TRS parts can be really tough on the surface after the molding process and they can ruin your files. The preliminary heat soak will remove any risk of encountering surface hardening. Finally, do not completely trust the witness marks on the lock plate. Usually the tumbler hole is marked accurately and you should establish that hole first before drilling any other holes. The position of the tumbler will determine all else internally including the position of the main spring.
dave