I've coned about 15 of them I guess. Most of them I had to tweak the load just a tad, because i changed what i built the load upon. Change barrel configuration, powder, ball size, patch, patch lube, even how many times you swab & what you swab with or not at all, will make a dif. most of the time. You change something, it usually changes the group or the POI. Some things effect it more than others.
After coning my .54 cal deer rifle, I had to bump it up 2 grains to get back to where I was. I have no issues
with it & just play with each one accordingly. Had a couple I had to do nothing. Never had any I felt I lost accuracy,
I just tweak the load a tad.