I most heartedly agree with the "use the most accurate reasonable load".
This means, if your load combination is so poor that 35gr. is the most accurate, you don't have a big game hunting rifle, no matter the caliber.
Here where we hunt, you might have a 10yard or 100yard shot, or maybe one at 150yards.
I do not consider 80gr. 2 or 3F as being a 150yard load in a .54. The velocity is so low, merely hitting in the rig. Dead moose 40yards from impact.
The hole through the lungs and heart was barely over 1/2", but it worked. Accuracy is much more important than "power", but - use as
much "power" as your rifle likes (wants you to use). Just because a load is deemed to be powerful enough, does not mean it is the best load, accuracy
wise, for your rifle.