You'll just have to try it, I guess. I have heard guys claiming that the use of wasp nest was a historical fact, however, I've never see this proven. Sam Fadala had to use a wad between powder and patched ball to prevent blowby and loss of velocity. His use of wasp's nest for this purpose in the 1970's was the first time I had ever heard of wasp nest use. This certainly was never mentioned (that I can recall) in Ned Robert's "The Muzzleloading Cap Lock Rifle", yet a lot of actual historical facts were noted.
From a practical standpoint, any card wad would work as well as wasp nest and be easier to use as well. I used a card wad in my 14 bore rifle to protect the powder from the lubed wad, until I experimented with and without and found the wad wasn't necessary. My chronograph proved this. I've always (since 1974 at least) used loads that sealed & these were loaded with the rifle's hickory rod, for hunting or target shooting. When testing loads, I use a range rod, though, to prevent having to remove and replace the rifle's rod every time I load.
