MUCH depends on the rate of twist in the rifling. Most pistols with appropriate rates of twist for a .50, would be in the 18" up to 24" range, for using small powder charges, ie: 25 to 35gr. If the barrel used has a slower rifling twist you will likely need greater powder charges yet, to get decent accuracy. It is all about accuracy and how you shoot it.
I have a slow, 66" twist barrel on my .54 pistol & it requires 55gr. 2F to shoot well, yet my .45 pistol barrel with 18" twist shoots exceptionally well with 25gr. & a round ball. The .45 even shoots well
with 200gr. slugs but with 35gr. of 3F.
Experiment!!