As Monk has noted, loose loads contribute to erosion ahead of the powder chamber due to the gas cutting effect of the powder gasses rushing past the patched ball. This, along with rod wear, contributes to the need for 'freshing' or re-cutting the rifling- especially in iron barrels. Steel barrels are more resistant to this type of erosion but are not immune to it, not even the 4140 & 4150 modern chromemoly barrel steels normally used in CF applications. I sincerely doubt, however, if cared for and cleaned properly, those barrels would EVER need freshing or re-cutting.
12L14, being quite soft in comparison, would likely need 'help' if shot a lot. 1075 or whatever GM uses, harder and more resistant, etc.
We have a fellow in our club who has over 10,000 shots fired from EACH of his flintlock guns. Aside from the odd main or feather spring and replacement frizzen, his guns keep on shooting well. He documents EVERY shot fried from them, in that he knows EXACTLY ow many shots each has fired, to the ball.