Forsyth wrote about a 13 bore rifle he once had, that with a load that would not strip in it's very fast twist, the rifle was next to useless for hunting as it had a 13" of trajectory over a distance 100yards.
As he noted, how do you hold a fine sighting, when having that much elevation - the gun has no point blank range at all. Where do you hold on a charging bear, hog or deer? deer?
I prefer to have a long point blank range, wherein I do not have to think about holding high or low, over a normal hunting distance, which around here would run from 50 to 125yards or so.
Thus, if the ball is no more than 3" above, nor below the line of sight, the ball will always hit inside that 6" killing zone and no allowance for trajectory needs be taken.
With the hunting load in my rifle giving 1,550fps, this is the trajectory and why I load it as I do, for hunting.