I've shot completely through a couple elk with .45cal. cast bullets, One went 70yards, and the other dropped at the shot. No expansion on either. Now, I kind of like a hole out the off side. If the animal decides to run, he's going to leak a bit of red. Without an exit wound, there is rarely a blood trail.
The do no run far with a .69 ball, non-expanding or soft lead, that makes it across the animal and they all do, leg bones or not. The animal might stagger 20 yards, or simply lay down.
I have also had expanding bullets stop inside moose. Most drop at the shot, while Taylor and I spend a couple hours tracking one moose, probably 1/2 mile, just by the way he was "throwing" a leg - by the tracks only - no blood - that was not fun.
If shooting a small ball - stay away form any bone on large bodied game. If shooting a larger ball, ribs are no problem, like a .54 or larger. I found pure or hardened .682" lead to work well on moose leg bones & the lungs before or after hitting the lungs - smashing good calibre!