Thanks, everyone, for your input.
I've heard the following views expressed:
1. a smaller caliber, more robust barrel (i.e., the .45) may be the more accurate choice for range shooting (with the obvious caveat that shooter skill trumps everything).
2. a heavier gun is superior for offhand range shooting
3. a lighter gun is superior for offhand range shooting
4. given the fact the Woodsrunner is a “lighter” gun in all calibers than Jim’s Colonial, a large bore Woodsrunner may present unpleasant recoil characteristics for a day of offhand range shooting at, say, 100 yards.
I’m interested to hear your thoughts about these viewpoints I’ve seen articulated by various folks...